Table 1 Multivariate analysis of MTHFD1 expression and overall survival in lung adenocarcinoma patients (TCGA dataset)

Age at initial diagnosis

1.004

0.988–1.020

0.63

Gender

1.003

0.737–1.364

0.99

Stage

< 0.001

 IB vs. IA

1.185

0.718–1.957

0.51

 IIA vs. IA

3.232

1.813–5.761

< 0.001

 IIB vs. IA

2.016

1.187–3.425

0.009

 IIIA vs. IA

3.441

2.080–5.694

< 0.001

 IIIB vs. IA

2.698

1.105–6.587

0.03

 IV vs. IA

3.939

2.092–7.416

< 0.001

 MTHFD1 (high vs. low)

1.713

< 0.001