Fig. 7
From: Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells
Contribution of glycolysis and gluconeogenesis to serine and glycine. A Comparison of label enrichments from 13C6-glucose or 13C5-glutamine in pools of serine and glycine. Results are shown as mean ± SEM from four (A549 and H1299) or three (BEC) experiments. The sum of all labeled isotopologues was used for group comparisons using Two-way ANOVA with Tukey post-hoc analysis; *P < 0.05; **P < 0.01; ***P < 0.001; n.s., not significant; # versus high glucose conditions. Ser/Gly, serine/glycine. B Model depicting variable contributions of uptake or de novo synthesis from glucose or gluconeogenesis to serine and glycine pools. 1C, one-carbon units; TCA, tricarboxylic acid cycle; PEP, phosphoenolpyruvate; 3-PG, 3-phosphoglycerate