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Fig. 6 | Cancer & Metabolism

Fig. 6

From: Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc–ODC1 nexus

Fig. 6

The polyamine metabolism regulated by ODC1 is involved in the modulation of the tumor phenotype by HIGD1A in HCC cells. A Simplified scheme of polyamine biosynthesis pathways. SPDS: spermidine synthase; SPMS: spermine synthase. B HPLC analysis showing that putrescine, spermidine, spermine, and cadaverine levels were significantly decreased in HepG2 and MHCC97H cells infected with shHIGD1A lentivirus compared with those in the shCtrl group. C CCK8 assay showing that exogenous polyamines attenuated shHIGD1A-induced inhibition of cell proliferation in HepG2 and MHCC97H cells. D Transwell assay showing that exogenous polyamines restored shHIGD1A-induced inhibition of cell migration in HepG2 and MHCC97H cells. E Transwell assay with Matrigel showed that exogenous polyamines restored shHIGD1A-induced inhibition of cell invasion in HepG2 and MHCC97H cells. Results shown are mean ± SEM. *P <0.05, **P <0.01, ***P <0.001. Scale bar, 100µm

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Cancer & Metabolism

ISSN: 2049-3002