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Table 3 Baseline characteristics stratified by CTI

From: Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

Variables

CTI < 4.71

CTI ≥ 4.71

P-value

 

(n = 763)

(n = 649)

 

Sex (%)

  

0.066

 Male

466(61.1)

428(65.9)

 

 Female

297(38.9)

221(34.1)

 

 Age (mean (SD))

58.27(11.66)

60.84(10.88)

 < 0.001

 BMI (mean (SD))

20.89(3.07)

21.17(3.31)

0.105

Tumor stage (%)

  

 < 0.001

 I

52(6.8)

31(4.8)

 

 II

174(22.8)

58(8.9)

 

 III

255(33.4)

161(24.8)

 

 IV

282(37.0)

399(61.5)

 

Tumor.type (%)

  

 < 0.001

 Lung cancer

169(22.1)

213(32.8)

 

 Gastric cancer

212(27.8)

102(15.7)

 

 Other digestive cancers

53(6.9)

66(10.2)

 

 Esophageal cancer

76(10.0)

53(8.2)

 

 Colorectal cancer

157(20.6)

120(18.5)

 

 Breast cancer

28(3.7)

18(2.8)

 

 Female reproductive cancer

19(2.5)

30(4.6)

 

 Urological cancer

12(1.6)

17(2.6)

 

 Nasopharyngeal cancer

26(3.4)

8(1.2)

 

 Other cancer

11(1.4)

22(3.4)

 

 Surgery, yes (%)

418(54.8)

266(41.0)

 < 0.001

 Radiotherapy, yes (%)

62(8.1)

74(11.4)

0.047

 Chemotherapy, yes (%)

418(54.8)

383(59.0)

0.122

 Tch, mmol/L (mean (SD))

4.46(1.04)

4.41(1.29)

0.396

 TG (mean (SD))

1.15(0.49)

1.53(1.07)

 < 0.001

 CRP (mean (SD))

3.64(3.05)

50.33(51.47)

 < 0.001

 CTI (mean (SD))

4.14(0.41)

5.32(0.42)

 < 0.001

 Glu (mean (SD))

5.33(1.14)

6.05(2.21)

 < 0.001

 Smoking, yes (%)

358(46.9)

353(54.4)

0.006

 drinking, yes (%)

196(25.7)

157(24.2)

0.558

 diabetes, yes (%)

45(5.9)

94(14.5)

 < 0.001

 hypertension, yes (%)

115(15.1)

140(21.6)

0.002

 CHD, yes (%)

29(3.8)

37(5.7)

0.119

 KPS (mean (SD))

85.54(11.42)

79.63(17.39)

 < 0.001

 QC30 (mean (SD))

47.85(12.87)

53.36(13.62)

 < 0.001

ECOG PS (%)

  

 < 0.001

  < 2

712(93.3)

522(80.4)

 

  ≥ 2

51(6.7)

127(19.6)

 

PGSGA (%)

  

0.003

 Well-nourished

8.89(3.92)

10.81(4.67)

 

 Malnutrition

722(94.6)

635(97.8)

 

 Nutrition intervention, yes (%)

160(21.0)

172(26.5)

0.017

 TSF (mean (SD))

13.52(6.64)

13.53(7.03)

0.978

  1. CTI CRP-TyG index, CRP C-reactive protein, TyG triglyceride-glucose index, BMI body mass index, CHD coronary heart disease, KPS karnofsky performance status, EORTC QLQ-C30 The European Organization for Research and Treatment of Cancer (EORTC), Quality of Life Questionnaire-Core 30 (QLQ-C30), ECOG PS eastern cooperative oncology group performance status, PGSGA Patient Generated Subjective Global Assessment, TSF triceps skinfold thickness