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Table 1 Baseline characteristics of this study population

From: Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

Variables

Total cohort

Internal test cohort

External validation cohort

p

 

(n = 1412)

(n = 420)

(n = 307)

 

Sex (%)

   

0.776

 Male

894(63.3)

258(61.4)

192(62.5)

 

 Female

518(36.7)

162(38.6)

115(37.5)

 

 Age (mean (SD))

59.45(11.38)

58.90(11.22)

61.16(11.58)

0.023

 BMI (mean (SD))

21.02(3.19)

21.27(3.31)

20.15(2.84)

 < 0.001

Tumor stage (%)

   

 < 0.001

 I

83(5.9)

25(6.0)

6(2.0)

 

 II

232(16.4)

59(14.0)

26(8.5)

 

 III

416(29.5)

128(30.5)

83(27.0)

 

 IV

681(48.2)

208(49.5)

192(62.5)

 

Tumor types (%)

   

0.005

 Lung cancer

382(27.1)

111(26.4)

73(23.8)

 

 Gastric cancer

314(22.2)

79(18.8)

72(23.5)

 

 Other digestive cancers

119(8.4)

33(7.9)

31(10.1)

 

 Esophageal cancer

129(9.1)

44(10.5)

23(7.5)

 

 Colorectal cancer

277(19.6)

79(18.8)

67(21.8)

 

 Breast cancer

46(3.3)

19(4.5)

5(1.6)

 

 Female reproductive cancer

49(3.5)

21(5.0)

11(3.6)

 

 Urological cancer

29(2.1)

14(3.3)

3(1.0)

 

 Nasopharyngeal cancer

34(2.4)

9(2.1)

2(0.7)

 

 Other cancer

33(2.3)

11(2.6)

20(6.5)

 

 Surgery, yes (%)

684(48.4)

217(51.7)

167(54.4)

0.122

 Radiotherapy, yes (%)

136(9.6)

44(10.5)

36(11.7)

0.522

 Chemotherapy, yes (%)

801(56.7)

242(57.6)

195(63.5)

0.091

 Tch, mmol/L (mean (SD))

4.44(1.16)

4.43(1.15)

4.37(1.17)

0.651

 TG (mean (SD))

1.33(0.83)

1.37(1.01)

1.28(0.73)

0.355

 TyG (mean (SD))

3.82(0.28)

3.83(0.29)

3.86(0.29)

0.137

 CRP (mean (SD))

25.10(41.99)

26.11(42.00)

25.01(37.09)

0.901

 CTI (mean (SD))

4.68(0.72)

4.72(0.72)

4.69(0.77)

0.62

 Glucose (mean (SD))

5.66(1.75)

5.74(2.04)

6.31(2.15)

 < 0.001

 Smoking, yes (%)

711(50.4)

205(48.8)

123(40.1)

0.005

 Drinking, yes (%)

353(25.0)

112(26.7)

88(28.7)

0.378

 Diabetes, yes (%)

139(9.8)

48(11.4)

27(8.8)

0.476

 Hypertension, yes (%)

255(18.1)

79(18.8)

83(27.0)

0.001

 CHD, yes (%)

66(4.7)

16(3.8)

6(2.0)

0.088

 KPS (mean (SD))

82.83(14.77)

83.52(13.87)

74.40(15.16)

 < 0.001

 QC30 (mean (SD))

50.38(13.50)

50.09(13.61)

57.26(16.41)

 < 0.001

ECOG PS (%)

   

 < 0.001

  < 2

1234 (87.4)

370 (88.1)

200 (65.1)

 

  ≥ 2

178 (12.6)

50 (11.9)

107 (34.9)

 

PGSGA (%)

   

0.682

 Well-nourished

55 (3.9)

19 (4.5)

10 (3.3)

 

 Malnutrition

1357 (96.1)

401 (95.5)

297 (96.7)

 

 Nutrition intervention, yes (%)

332 (23.5)

99 (23.6)

185 (60.3)

 < 0.001

 TSF (mean (SD))

13.53 (6.82)

13.57 (7.11)

20.54 (15.73)

 < 0.001

  1. CTI CRP-TyG index, CRP C-reactive protein, TyG triglyceride-glucose index, BMI body mass index, CHD coronary heart disease, KPS karnofsky performance status, EORTC QLQ-C30 The European Organization for Research and Treatment of Cancer (EORTC), Quality of Life Questionnaire-Core 30 (QLQ-C30), ECOG PS eastern cooperative oncology group performance status, PGSGA Patient Generated Subjective Global Assessment, TSF triceps skinfold thickness