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Fig. 7 | Cancer & Metabolism

Fig. 7

From: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response

Fig. 7

PDE6H knockout and sildenafil treatment effect on tumour in HCT116 xenograft model. a IHC analysis for markers for proliferation and hypoxia signalling. b Tumour growth curves of ctrl- and sildenafil-treated mice of mock or PDE6H KO HCT116 xenograft models. c Average tumour volumes of treatment groups on day 28 and median survivals of treatment groups. All subjects are shown in b, while welfare culls are omitted from c in accordance with the criteria described in “Methods”. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cancer & Metabolism

ISSN: 2049-3002