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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response

Fig. 1

Knockdown of metabolic genes caused G1/S or G2/M arrest in HCT116 cells. a G1/S arrest and b G2/M arrest inducing siRNAs, which caused an increase in G1 population of > 0.15 or G2 population of > 0.25. The mean of normalised differences in G1 or G2 populations were greater than two standard deviations for the siRNAs presented. Hits shown have caused an unnormalized increase of > 5% in G1 or G2 populations, in at least two independent screens where n = 3. c Percentage of cells with sub-G1 DNA content were presented as an estimate of cell death. Genes, the knockdowns of which caused a sub-G1 population greater than 4%, are presented. The means are shown; error bars represent SD (n = 3). d KEGG pathway classification of G1/S targets and of e G2/M targets

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Cancer & Metabolism

ISSN: 2049-3002