From: Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
Amino acid | Fold change—mutant IDH1 vs non-mutant Chondrosarcoma | p-value | Fold change—mutant IDH2 vs non-mutant Chondrosarcoma | p-value |
---|---|---|---|---|
Glucogenic amino acids | ||||
 Val | 2.8 | 0.0015* | 3.6 | 0.1275 |
 Met | 2.7 | 0.0156* | 4.5 | 0.1989 |
 His | 2.6 | 0.0071* | 3.4 | 0.0703 |
 Arg | 1.5 | 0.1729 | 3.8 | 0.3309 |
 Gly | 3.1 | 0.0174* | 3.4 | 0.0497* |
 Gln | 2.8 | 0.0950 | 3.7 | 0.0222* |
 Pro | 4.5 | 0.0021* | 5.7 | 0.0404* |
 Ser | 2.8 | 0.0502* | 4.5 | 0.0487* |
 Asp | 4.0 | 0.0639 | 5.8 | 0.0125* |
 Asn | 3.0 | 0.0340* | 6.0 | 0.1083 |
 Ala | 3.4 | 0.0080* | 3.2 | 0.0659 |
 Glu | 3.2 | 0.0680 | 4.3 | 0.0594 |
Ketogenic amino acids | ||||
 Leu/ Ile | 3.2 | 0.0021* | 4.8 | 0.1097 |
Glucogenic & ketogenic amino acids | ||||
 Phe | 3.3 | 0.0099* | 4.9 | 0.1459 |
 Tyr | 3.3 | 0.0068* | 4.5 | 0.1403 |
Other amino acids | ||||
 Orn | 2.0 | 0.0128* | 1.5 | 0.2156 |
 Cit | 2.8 | 0.0667 | 2.8 | 0.1950 |